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货号 | RC0285 |
| 名称 | 萘普生；(S)-Naproxen |
| 说明书 | |
| CAS号 | 22204-53-1 |
| 分子式 | C14H14O3 |
| 分子量 | 230.27 |
| 储运 | RT |
| 外观 | 白色结晶性粉末 |
| 可溶性/溶解性 | water : 75 mg/mL (325.72 mM; Need ultrasonic and warming) DMSO : ≥ 30 mg/mL (130.29 mM) |
| 靶点 | COX |
| 体外研究 | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively. |
| 体内研究 | Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM). |
